初燕燕，博士，正高级工程师，现任潍坊科技学院化工与环境学院教授。研究领域为计算机辅助药物设计、数据驱动的药物发现。

主要采用计算机辅助药物设计和人工智能的方法，从事小分子先导化合物和多肽药物的发现、设计与构-效关系研究；通过干湿结合研究离子通道变构机制，并寻找干预其变构的活性肽。在国际期刊发表论文近20篇，以第一作者或通讯作者发表SCI论文10余篇；授权国家发明专利1项，国际专利1项。承担项目有国家自然科学基金和山东省自然科学基金。

代表性论文

1. Yanyan Chu*, Huanhuan Zhang, Mengke Yang, Rilei Yu*. 2023, Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1. IJMS, 24: 9553.

2. Yanyan Chu*, Huanhuan Zhang, and Lei Zhang. 2022. Function Prediction of Peptide Toxins with Sequence-Based Multi-Tasking PU Learning Method. Toxins 14, 11: 811.

3. YanYan Chu*, PeiJuQiu, and RiLei Yu*. 2020. Centipede Venom Peptides Acting on Ion Channels. Toxins 12, 4: 230.

4. Ningning Wei^#, Yanyan Chu^#, Huijie Liu, Qingliang Xu, Tao Jiang*, and Rilei Yu*. 2021. Antagonistic Mechanism of α-Conotoxin BuIA toward the Human α3β2 Nicotinic Acetylcholine Receptor. ACS Chemical Neuroscience 12, 24: 4535–4545.

5. Yanyan Chu, Zhenhua Tian, Yingwei Hou, and Wenbao Li*. 2018. Study on the Preparation and Antileukemic Activity of New Lipophilic 1-β-D-arabinofuranosylcytosine Derivatives. Journal of Ocean University of China 17, 2: 385–391.

6. Rilei Yu^#, Huijie Liu^#, Baishi Wang^#, Peta J. Harvey, Ningning Wei*, and Yanyan Chu*. 2020. Synthesis and biological activity study of the retro-isomer of RhTx against TRPV1. RSC Advances 10, 4: 2141–2145.

7. Yanyan Chu*, Zhenhua Tian, Mengke Yang, and Wenbao Li. 2022. Conformation and energy investigation of microtubule longitudinal dynamic instability induced by natural products. Chemical Biology & Drug Design: cbdd.14189.

8. 赵广健，翟德设，于日磊，李以诺，李俪，徐锡明，初燕燕*，2020. 苦木注射液成分抑制SARS-CoV-2的研究，中国海洋大学学报（自然科学版），51, 01: 70–75.

9. QiaoboXie, Yanyan Chu, Wenmin Yuan, Yanan Li, Keqin Li, Xinfeng Wu, Xiaohui Liu, Rui Xu, Shuxiang Cui, Xianjun Qu. 2023. Activation of insulin-like growth factor-1 receptor (IGF-1R) promotes growth of colorectal cancer through triggering the MEX3A-mediated degradation of RIG-I. Acta PharmaceuticaSinica B: S221138352300117X.

10. Xiao Li, Han-Shen Tae, Yanyan Chu, Tao Jiang, David J. Adams, and Rilei Yu. 2021. Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor. Pharmacology & Therapeutics 222: 107792.

11. He Ma, PeijuQiu, Huixin Xu, Ximing Xu, Meng Xin, Yanyan Chu, Huashi Guan, Chunxia Li, Jinbo Yang. 2019. The Inhibitory Effect of Propylene Glycol Alginate Sodium Sulfate on Fibroblast Growth Factor 2-Mediated Angiogenesis and Invasion in Murine Melanoma B16-F10 Cells In Vitro. Marine Drugs 17, 5: 257.

专利

1.初燕燕，杨金波，王卓亚，赵晨阳，于日磊，李俪，杨萌琳，氯生太尔或其药学上可接受的盐在制备用于预防和/或治疗冠状病毒感染的药物中的应用，授权时间：2022.03，专利号：ZL202011135777.0

2.Chen Huifen, Chu Yanyan#, Do Steven, et al., Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators, 授权时间：2022.02，专利号：US11236046B2.

项目课题

1.国家自然科学基金，2022-2024，在研，主持。

2.山东省自然科学基金，2021-2023，结题，